Sloki provides NGS data analysis for comparative genomics, high-throughput polymorphism detection,analysis of coding and non-coding RNAs and identifying mutant genes in disease pathways.
Protein Structure-function analysis
At Sloki, we analyze the contribution of amino acid mutation towards the change in protein structure conformation and further its effect on functionality.
Data mining and Database Development
We curate the information in custom designed formats and create an ontological database.
Sloki helps you in research hypothesis, data management and data analysis.
Sloki provides technical writing support which involves communicating complex information to those who need it to accomplish some task or goal like thesis, research articles etc.
Hit to Lead identification
At Sloki, we perform the “automatically evaluating very large libraries of compounds” using computer programs. We work for Hit to lead (H2L) approach of early drug discovery where small molecule hits from a highthroughput screen (HTS) are evaluated and undergo limited optimization to identify promising lead compounds. Further Optimization is accomplished through chemical modification by employing knowledge of the structure-activity relationship (SAR).
Molecular Docking and Dynamics Simulation Studies
We focus on molecular recognition process by using molecular docking and dynamics simulation. It aims to achieve an optimized conformation for both the DNA-Ligand or Protein-Ligand or Protein-Protein interaction such that the free energy of the overall system is minimized.
Structural Bioinformatics Services
Protein and small molecule Structure determination
We help in determination of crystal structure either of protein or small molecule. We support you towards understanding the functionality of the structure by generating high quality images like the packing diagrams etc. which helps to communicate your work to peer reviewed journals for the publications
Data Analysis and algorithm development
Sloki has rich experience in structural bioinformatics. We pioneered in data extraction from biological sequence or structural databases and developing new methodology or algorithm to solve biological problems.
Python Based Bioinformatics Software Development
Bio-python is a collection of python modules that facilitate the development of python scripts for bioinformatics applications. Bio-python provides reusable python modules that facilitate writing scripts for sequence manipulation, accessing of databases using a range of data formats and execution and parsing of the results of various molecular biology programs. Consequently, Bio-python enables developing scripts that can analyze large quantities of sequence data in ways that are typically difficult or impossible with web based systems.
Sensors for Human Health
Sloki is dedicated towards developing an analytical device for the detection of an analyte that combines a biological component with a physicochemical detector. We can detect the sensitive biological element (e.g. tissue, microorganisms, organelles, cell receptors, enzymes, antibodies, nucleic acids, etc.), a biologically derived material or biomimetic component that interacts (binds or recognizes) the analyse under study. The biologically sensitive elements can also be created by biological engineering. We use the transducer or the detector element (works in a physiochemical way; optical, piezoelectric, electrochemical, etc.) that transforms the signal resulting from the interaction of the analyse with the biological element into another signal (i.e., transducers) that can be more easily measured and quantified.
BIOINFORMATICS AND IN SILICO DRUG DISCOVERY
- Introduction to biological databases and information retrieval from biological databases
- DNA and protein sequence analysis using pairwise and multiple sequence alignment (Local and Global)
- Phylogenetic analysis using MEGA6
- Retrieval of protein structure from PDB and its structure quality analysis
- Protein structure modelling and its quality assessment
- In-silico drug design, protein-ligand, DNA-ligand docking
- Visualization tools (Rasmol, Pymol) to view the 3D structure of the molecule.